The influence of the variables methanol concentration, solvent/ solid ratio, and time on the extraction of antioxidant phenolic compounds from SCG was investigated through a 2 3 full factorial design and a 2 2 central composite design. The real and coded values of the variables for the experimental designs are given in Tables 1 and 2. Statistical significance of the variables was determined at the 5% probability level (p< 0.05). The data obtained from the 2 2 experimental design were fitted to second order polynomial equations and where possible the models were simplified by elimination of statistically insignificant terms. Statistical significance of the regression coefficients was determined by Student’t test, and the proportion of variance explained by the models were given by the multiple coefficient of determination,R 2 . Statistical analysis of the data as well as the determination of the conditions able to maximize the extraction results were performed using the softwares Statistica (version 8.0), and Design expert (version 5.0). Assays to validate the optimum extraction conditions as well as the analysis for characterization of the produced extracts were performed in triplicate