SEM observations allowed understanding the bond between the glass grains and the chitosan matrix.
In vitro results showed that scaffolds form a hydroxyapatite (HA) Ca10(PO4)6(OH)2 after 15 days of immersion
in a simulated body fluid (SBF).The interest of this study is to see that the increase of the content of
bioactive glass in the chitosan matrix slows the release of gentamicin sulfate in the liquid medium. Starting
concentration of gentamicin sulfate has an influence on the relaxation time of the scaffolds. Indeed,
an increasing concentration delays the return to a new equilibrium. Contents of chitosan and bioactive
glass do not affect the relaxation time. Synthesized scaffolds could be adapted to a clinical situation:
severity and type of infection, weight and age of the patient