HT is also a potent radiation sensitizer.[10] Cellular
hypoxia induces resistance to radiation. Moderate HT leads
to increased vascular permeability and increase in oxygen
pressure levels in the tumors. This altered microenvironment
due to HT enhances the radiosensitivity of the tumor. Thermal
radiation sensitization may also be due to DNA inhibition of
repair and alteration in nuclear protein aggregation and higher
order chromatin organization.[9]