Dengue viruses are arboviruses of the Flavivirus genus (Guzman
et al., 2010) found as four distinct serotypes (DENV1–4). They
cause an acute febrile illness called dengue, which may develop in
different degrees of manifestations that were classified by WHO as
dengue fever, dengue with alarm symptoms and severe dengue
(Horstick et al., 2015). It is estimated that over 300 million people
are infected by any of the DENV serotypes per year worldwide and,
at least, 90 million develop the severe forms of the disease (Bhatt
et al., 2013). Despite the high epidemiological relevance of the
disease, no effective vaccine formulation is presently approved for
use in humans.