Formulation containing free OMC
In order to establish a comparison with the liposome/OMC formulation, a gel formulation containing 8% free OMC was prepared. The formulation components and their concentrations are reported in Table 1. Methylparaben was solubilized in hot water, after which Aristoflex was slowly added to the water with vigorous mixing. The polysorbate 80 was then added, and finally OMC was incorporated into the formulation.