Due to lack of information about alkaline sludge treatment with high dose at ambient temperature, alkaline sludge treatment was investigated to know the effects of different doses (0–0.5 mol/L) of sodium hydroxide (NaOH) and calcium hydroxide [Ca(OH)2] at 0–40 °C. Results showed that NaOH was more suitable than Ca(OH)2 for sludge disintegration. For NaOH treatment, most efficient dose was about 0.05 mol/L (0.16 g/g dry solid), and 60–71% solubilization of organic matters was achieved in first 30 min during its treatment of 24 h. The process is described by a transmutative power function model, and relation between reaction rate constant and temperature are according with Arrhenius equation. Low dose NaOH treatment (