The objective of this research is to select yeast strains and yeast assimilable nitrogen (YAN) level suitable for a production of Hong-huay lychee wine. The lychee juice was fermented with two different yeast strains (V 1116 and ICV GRE), and three different levels of YAN (140, 190 and 240 mgN/L). The must was adjusted to 2 g/L total acidity, 200 g/L sugar content, and incubated at 15 °C. The result showed that the wine samples contained 7.29- 8.71 g/L total acidity, 5.87-7.47 % total soluble solids, and 8.52-9.23 % (vol.) ethanol content. It indicated that the yeast strains and YAN levels affected the acid accumulation of the final products. The strain ICV GRE produced less acid content than strain V 1116. The addition of YAN produced the