Triphala is novel dietary or natural chemopreventive
formulation. Triphala has been used for centuries in
Ayurvedic medicine to treat various types of
gastrointestinal-related disorders; however, the molecular
mechanisms of triphala have not been studied yet. In the
present studies, it has demonstrated that aqueous extract of
triphala is effective in inhibiting the growth of pancreatic
cancer cells in culture as well as in the In vivo model. The
results reveal that Triphala treatment drastically reduces the
survival of Capan-2 and BxPC-3 human pancreatic cancer
cells in a dose- dependent manner. On the other hand,
Triphala failed to cause any cytotoxic effects on the growth
of HPDE-6 near normal pancreatic epithelial cells.
Suppression of pancreatic cancer cell growth by Triphala in
studied model was due to induction of apoptosis, which in