Most ELBW and VLBW infants will experience periods of acute or chronic anemia due to loss of RBC on hemorrhagic anemia; increased destruction of RBC, on hypoplastic anemia; or loss due to blood draws. Infants with blood loss due to acute anemia could experience peripeheral vasoconstriction, causing a reduction of blood flow to the bowel. Infants who experience chronic anemia are not likely to experience the same amount of vasoconstriction as infants with acute anemia; however, there is a reduction in the infant's ability to oxgenate the blood. The administration of PRC can dilute the intravascular volume leading to hypoxia, causing the body to protect major organs by diverting blood alway from the bowel.