A
ntipsychotic medication constitutes the basic treatment
of psychotic symptoms. Despite the indisputable positive
effect on the overall clinical outcome,
1
it has become increasingly
recognized that antipsychotics are associated with metabolic
side effects and weight gain.
2–4
With the introduction of the
second-generation antipsychotics, especially clozapine and
olanzapine, this problem has become even more evident.
5,6
Increased body weight is an important risk factor for
development of central obesity, insulin resistance, type 2
diabetes, dyslipidemia, and hypertension, conditions that
in turn dramatically increase the risk of cardiovascular
disease.
7,8
Therefore, the increased mortality and morbidity
inherent in severe mental illness is complicated by the fact
that the necessary antipsychotic treatment is associated with
dysmetabolism that in turn further compromises quality of life
and life expectancy.
Antipsychotic medication constitutes the basic treatmentof psychotic symptoms. Despite the indisputable positiveeffect on the overall clinical outcome,1it has become increasinglyrecognized that antipsychotics are associated with metabolicside effects and weight gain.2–4With the introduction of thesecond-generation antipsychotics, especially clozapine andolanzapine, this problem has become even more evident.5,6Increased body weight is an important risk factor fordevelopment of central obesity, insulin resistance, type 2diabetes, dyslipidemia, and hypertension, conditions thatin turn dramatically increase the risk of cardiovasculardisease.7,8Therefore, the increased mortality and morbidityinherent in severe mental illness is complicated by the factthat the necessary antipsychotic treatment is associated withdysmetabolism that in turn further compromises quality of lifeand life expectancy.
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