For the SC-TCD, two-step anisotropic etching of silicon is per-formed. First, a shallow depth of 2–3 m (Fig. 1 – b1) is achievedwhich prevents the contact between the metal interconnects onthe Borofloat wafer and the walls of the separation column in sil-icon upon bonding. Second, a 2 m long, 70 m wide and 240 mdeep channel is etched into silicon wafer (Fig. 1 – b2). TCD resis-tors are fabricated on a glass substrate using a lift-off process fora 40 nm/100 nm/25 nm Cr/Ni/Au stack deposited employing the e-beam evaporator. The glass and silicon substrates are then alignedand bonded together (Fig. 1 – b3). The heaters and temperaturesensors are fabricated on the backside of the chip using stainlesssteel shadow mask (Fig. 1 – b4). Afterwards, the capillary tubes areepoxied into the inlet/outlet ports. The chip is finally coated witha thin layer (∼250 nm) of OV-1 on the walls of the column channel(Fig. 1 – b5). An SEM image of the Tenax TA and OV-1 coating isFig