The utilization of UHPLC/QToF-MS provided qualitative information about TPs without a prioriknowledge as the full scan MS data acquisition enables flexibil-ity in post-acquisition data processing. The time-trend criterion applied to retain only TPs with some persistence was essentialin reducing data processing time. Additionally, the high resolu-tion accurate mass data ensured the reliability when comparing the candidate lists to the list of predicted/expected TPs. In total, 16TPs stemming from 9 parent pharmaceuticals were identified in thewater/sediment test system. The accuracy of the overall approach was shown by the confirmation of all the 11 identified TPs for which reference standards were available.