Many emerging health issues are linked to increasing contact between humans and animals, the industrialization of food production, and environmental pollution. Global change has created new threats to the health of both animals and humans. These complex interactions impacting human health require to be dealt with by applying an integrative health risk management approach, which acknowledges the systemic interconnections of human, animal and environmental health. In addition, this approach includes the factors of prevention, intervention and recovery/rehabilitation. Being a global movement at the interface of science, society, policy and practice, One Health is, therefore, also deeply interdisciplinary and cross-sectorial.