With HPLC methods the use of expensive equipments
and the demand for more operator attention prevent their application in small industrial laboratories where only
a few analyses are performed each day (Alpdogan et al.,
2002; Zhang et al., 2005). Other methods such as FT infrared,
Raman and NIR reflectance spectrometry are equally
versatile for the measurement of caffeine and do not require
expensive chemicals, however, such instruments are expensive
and are not available in most laboratories.