The predominant oral yeast isolated from dentures has been identified as C. albicans,37 and was assessed in the present study. C. albicans was detected in all samples of all experimental groups (Fig. 5a). Cleanser tablet use for overnight denture storage revealed a promising potential to decrease the Candida infection incidence. This finding encourages further research on the optimization of the composition of alkaline peroxide-based tablets in order to inhibit Candida colonization of acrylic dentures. Furthermore, the presence of decreased amounts of C. albicansin the TABLET compared to the WATER group provided evidence that the addition of a cleansing tablet to water for nocturnal denture care do modulate the C. albicansdenture colonization (Fig. 5b). In contrast to the microbiota-related results where the beneficial effect of tablet nocturnal treatment was most striking when comparing to dry storage, C. albicans data provided evidence for the positive effect of the addition of a cleansing tablet to water (WATER vs TABLET). Compiling both microbial and Candida outcomes provides evidence for clinical recommendation of overnight denture storage by means of an effervescent alkaline peroxide-based tablet, in particular in situations where oral and denture hygiene is compromised.