the search for new therapeutic alternatives requires the development of adequate animal models of muscle lesion.
in this perspective, the availability of an animal model that mimics the characteristics of human muscle injury is crucial to study the pathophysiological mechanisms of regeneration and possible therapies.
many animal models of muscle injury have been proposed such as injection of cardiotoxin, mdx transgenic mice, crioinjury, manual clanping, laceration, strain and induced by exercise but none reproduces re-injuries which are the most common type of damage in the orthopedic field.