Trajectory analysis may be a useful strategy to reduce
heterogeneity in schizophrenia, and provide insight into
clinically meaningful subgroups of patients. Previous
trajectory analyses have used parametric techniques, with
sample sizes at least as large as that available in the present
analysis,5–9,21–23 and some with 10 times more patients.
These studies often discern 4 or more trajectory classes, but
with some as small as 2% or less of the sample.