Accelerated purine nucleotide degradation can also cause hyperuricemia , i.e., with conditions of rapid cell turnover, proliferation , or cell death , as in leukemic blast crises, cytotoxic therapy for malignancy, hemolysis, or rhabdomyolysis. Hyperuricemia can result from excessive degradation of skeletal muscle ATP after strenuous physical exercise or status epilepticus and in glycogen storage diseases types III , V, and VII. The hyperuricemia of myocardial infarction, smoke inhalation, and acute respiratory failure may also be related to accelerated breakdown of ATP.