In clinical tests, the antimicrobial activity of extracts from the Sala (Couroupita guianensis Aubl.) tissues were measured against 12 gram positive, 12 gram negative, and one protozoan. Methanol extracts of leaves, flowers, fruit, stem and root barks, and stem and root heartwood of the plant inhibited growth of the microorganisms, a phenomena that was enhanced by further fractionation of the methanol extracts into petrol, dichloromethane, ethyl acetate and butanol soluble fractions. Most activity was in the petrol fractions of the flowers, fruit, and stem bark; the ethyl acetate fraction of the flowers, and stem and root bark; and the dichloromethane fractions of the stem and root barks.