The second strategy involves prevention the formation of a lowpH
induced conformation of hemagglutinin, a key step leading to
fusion of the host endosomal membrane and the viral lipid
envelop. The antiviral activity of this group of compounds is
derived from their capability of stabilizing the nonfusogenic
conformation of the hemagglutinin. The first compound in this
class is tert-butylhydroquinone, which was discovered in 199360.