corresponding to the systolic phase. The cuff inflates only during the diastolic phase when venous blood is returning to the heart, thereby reinforcing the muscle-pump action on the peripheral circulation of venous blood and lymph. Arterial pulse waves detected in the earlobe or digit tip determine the cardiac phases and activate the air pump to transmit pressure to the cuffs only during the diastolic phase (Fig 2). The diastolic phase is detected by the photo-pulse sensor that measures the peak a11d bottom of the arterial wave and triggers the air pump. Pressure in the cuffs can be regulated at 3 designated levels: low (≈40 mmHg), normal (60 mmHg) or high (80 mmHg). This makes it possible to select a pressure that feels comfortable for the subject and only constricts the veins without affecting the arteries. The 4 cuffs applied to the legs (ie, a total of 8 cuffs) are programmed to apply sequential pressure for 15 min starting from the feet and continuing to the thighs in recurring cycles (beat-to- beat) (Fig 1). The subject lies prone on a bed and during the initial 15-min stage (pre-PS-AM stage) no cuff-pressure is applied. The PS-AM is then activated for 15min (PS-AM stage), followed by a further 15-min during which no cuff- pressure is applied (post-PS-AM stage).