The leaves of Crinum asiaticum are used as traditional heal- ers in North east Solomon Islands to treat inflammation (Wiart, 2000). Leaves are used for the treatment of skin disease and inflammation. It has antibacterial activity (Ilavenil et al., 2010). It is also used to treat ulcer and swelling (Goeltenboth et al., 1991). The seeds are considered as purgative (Duke and Ayensu, 1985). In Trobriands, the stem fibers are used for the treatment of Gonorrhoea. Hence, the present study is aimed to investigate ameliorative potential of C. asiaticum on hyperglycemia-mediated oxidative stress and hepatocyte dysfunction in alloxan induced diabetic rats