the resultant disorganized scar tissue that often replaces damaged myofibers may contribute to muscle injuries recurrence.
therapeutic intervention to treat skeletal muscle injury is controvertial. common treatments for skeletal muscle injuries are rest, ice, compression, and elevation, nonsteroidal anti-in-flammatory drugs, pulsed ultrasound and immobilization.
however, none of them treats the main problem, e.g. skeletal muscle cell loss and scar tissue formation.
also, routine treatments do not improve satellite cells number, proliferetion and differentiation.
therefore, efforts to develop treatments to promote faster and more complete recovery after muscle injury should be focused on the enhancement of muscle regeneration and/or the prevention of fibrosis.