Sam Lawton is on his way to a company retreat with his colleagues. While their bus crosses the North Bay Bridge, Sam has a premonition that the bridge will collapse, killing him and everyone on it, except his ex-girlfriend Molly Harper, who he gets safely across the bridge. In a panic, he persuades Molly, his friends Nathan Sears and Peter Friedkin, Peter's girlfriend Candice Hooper, his boss Dennis Lapman, Candice's rival Olivia Castle, and co-worker Isaac Palmer to leave the bridge before it collapses, killing the remaining people on it. FBI agent Jim Block doesn't believe that Sam is responsible for the bridge collapse, but promises to keep his eye on him. Following the memorial service, coroner William Bludworth mysteriously tells the survivors that "Death doesn't like to be cheated" and warns them to be careful. Believing this to be just some nonsense, they ignore his warnings and leave.
Later, Candice goes to gymnastics practice with Peter. A chain reaction causes her to fall off the uneven bars, snapping her spine and killing her, leaving Peter devastated. The next day, Isaac is killed when his head is crushed by a falling Budai statue during an acupuncture session at a Chinese spa. Bludworth, who has been present for both deaths, tells the remaining survivors that if they wish to cheat Death, they must kill someone who was never meant to die on the bridge, and thereby claim their remaining lifespan. On the same day, Olivia goes to an eye surgery clinic to treat her myopic vision. While the eye doctor is out looking for files, the laser malfunctions, searing her eye and hand. She manages to break free as Sam and Molly arrive to save her, but she trips and falls out of the window onto a car and dies instantly. Later, Sam and Molly study Death's design and realize that Nathan is next on Death's list.
Meanwhile, Nathan, who has returned to the plant, accidentally kills his co-worker Roy Carson during an argument by pushing him into the path of a lifting hook, which impales his chin. Nathan relays this information to the remaining survivors, who suggest he may have claimed Roy's remaining lifespan and thus he is safe. Dennis arrives to question Nathan about the incident, when a wrench launched by a belt sander suddenly hits Dennis in the face, killing him. That evening, Sam works at a restaurant, and after work asks his supervisor to reserve the restaurant for a date with Molly.
Peter, who has become paranoid and insane by Candice's death, interrupts the date to tell them that he convinced himself that he would be able to kill someone else in order to take their lifespan, and has decided to kill Molly. After Peter draws a gun and fires shots, Sam and Molly both escape to the restaurant's kitchen. Outside, Agent Block overhears the shots and enters the restaurant, but is killed by Peter. Believing that he is now safe from Death, Peter decides to kill both Molly and Sam to remove any witnesses. Peter is about to stab Molly with a kitchen knife, but Sam intervenes by stabbing him in the back with a large skewer, leading Sam to believe he has claimed Block's life.
Two weeks later, Sam and Molly board Volée Airlines Flight 180 to Paris. As they take their seats, a fight breaks out between two passengers (Alex Browning and Carter Horton), resulting in a handful of passengers being removed from the plane. Upon takeoff, Sam overhears that one of the passengers had a vision that the plane would explode, but its too late to leave the plane, and both he and Molly die in the resulting explosion. Meanwhile, at Roy's memorial, Nathan learns from a co-worker that Roy's autopsy revealed he had a brain aneurysm that would have burst "any day now". As Nathan realizes he is still in danger, the landing gear from Flight 180 crashes through the roof and crushes him.