This indicates that at these dose levels, there is a possibility of liver damage on long term exposure. Increases in ALP activities have been reported on administration of trona (Ajiboye et al., 2013) [16]. Ajiboye et al. (2015) [16] also reported a dose dependent reduction in the activities of SOD and Catalase in the liver of male wistar rats. This is consistent with the report of this study. The effect of trona on the kidney is not so pronounced; as most markers of renal function were not significantly affected.