They reported that the nanorods were taken up to a lesser extent than were the spherical nanoparticles based on the “weight of nanoparticles” in cells. These results seem to be inconsistent with our data. However, as each Sphere40 is 15-fold heavier than each rod, Figure 4A shows that the Sphere40s were more efficiently internalized into cells than rods when compared in terms of the weight of nanoparticles in a single cell. However, it should be noted that the number of internalized rods was 6 times higher than that of Sphere40s, meaning that Rod-Es can deliver WNVE antigens more efficiently into macrophages. Since Sphere40-Es induced the highest level of antibodies, the trend in antibody production shown in Figure 3 cannot be explained by the number of internalized AuNP-Es. This implies that there is another factor beyond the amount of antigen internalized.