The particle of MP-LRS3 was smaller and relatively smoother while
UP-LRS3 was bigger and rougher compared to GP-LRS3 by ESEM.
Among these samples, the crystallinity of GP-LRS3 was the greatest
observed by X-ray diffraction. GP-LRS3 exhibited the highest the
degree of ordered structure and the amorphous region of MPLRS3
was biggest by FT-IR and 13C NMR as well as UP-LRS3 displayed
the highest degree of double helical structure. These results
indicated that the structure of LRS3 was influenced by the preparation
methods. In addition, MP-LRS3 displayed the greatest solubility
and swelling power, which were affected by the amorphous
region, particle structure.