Figure 8 shows the ultrastructural details of the tip of a lateral branch of hyphae after treatment with 0.001 mg ml—1 micafungin for 5 h. At the tip of the branch, many electron- dense inclusions, varying in size and shape, were observed within the cell wall and the space between the wall and the cell membrane, although no remarkable ultrastructural change was found in the cytoplasm of the branch (Fig. 8). A TEM image of disrupted hyphal tips, one of the most noticeable micafungin-induced morphological changes is illustrated in Fig. 9. Most parts of the cell wall and cell membrane of the apical cell were lost (or hardly observed) after 2 h treatment with 0.01 mg ml—1 micafungin (Fig. 9).