Abstract Background. Serum levels of gastrin-17(S-G-17 and pepsinogen I (S-PGnare biomark- of gastric antral and corpus mucosa, respectively. We determined whether these tests, together with the assay of Helicobacter pylori antibodies, are a nonendoscopic tool for the diagnosis atrophic gastritis. Objectives: To study the relation between H. pylori infection and atrophic gastritis in the elderly through the estimation of gastrin 17 and pepsinogen I as novel noninvasive diagnostic biomarkers. Material and methods: The present study included sixty individuals suffering from gastritis there were divided into two groups. Group Thirty patients having H. pylori infection aged above 65 years. Group (II: Thirty patients without H. pylori infection aged above 65 years. All individu- alswere subjected to diagnostic upper-gastrointestinal endoscopy and specific gastric biomarkers (serum gastrin-17, serum pepsinogen