60-75 mg/m2 BSA or 1.2-2.4 mg/kg body wt as a single IV inj at 3-wk intervals. 20-25 mg/m2 BSA/day or 0.4-0.8 mg/kg body wt/day for 3 successive days as an IV inj at 3-wk intervals. In combination w/ other chemotherapeutic agents, 30-40 mg/m2 body surface as IV. Bilirubin 1.2-3 mg/100 mL or BSP 9-15% Reduce to 50% of normal dose; Bilirubin >3 mg/100 mL or BSP >15% Reduce to 75% of normal dose. Total dose should not be >550 mg/m2 body surface.