Table 1
Various PKC isoforms and known effects on lipid homeostasis.
Type Isoform Cofactor dependence In vitro adipocyte differentiation Effect of deletion on lipid homeostasis
Classical α DAG, lipid, Ca2+ Inhibit No effect
β Promote Reduced lipid accumulation in WAT, liver, and muscle
γ No effect No effect
Novel δ, DAG, lipid Promote No effect
ε Promote Promotes hepatic lipid accumulation, reduced release of fatty acids by adipose tissue
θ Inhibit Visceral adipose tissue accumulation
Atypical ι/λ PAR6–CDC42 Promote Reduced hepatic steatosis
Table 1Various PKC isoforms and known effects on lipid homeostasis.Type Isoform Cofactor dependence In vitro adipocyte differentiation Effect of deletion on lipid homeostasisClassical α DAG, lipid, Ca2+ Inhibit No effectβ Promote Reduced lipid accumulation in WAT, liver, and muscleγ No effect No effectNovel δ, DAG, lipid Promote No effectε Promote Promotes hepatic lipid accumulation, reduced release of fatty acids by adipose tissueθ Inhibit Visceral adipose tissue accumulationAtypical ι/λ PAR6–CDC42 Promote Reduced hepatic steatosis
การแปล กรุณารอสักครู่..