The insulin responds altering. So, these hormones are very much necessary to physiology together. And when a normal people feel well when they able to manage stress and emotional stress, physical stress, when everything good to their bodies and it's in balance and also when the thyroid in the function normally, they'll feel normal, they'll feel good but if they get too much of those pressure they might lead to a logic problem, and so, you can see these patients walk into your office everyday.