Propentofylline and dementia: mode of action. Propentofylline inhibits cytotoxic functions of activated
microglia and also modulates astrocyte functions by stimulating NGF synthesis/secretion. It improves
learning and memory in experimental models of dementia and enhances hippocampal LTP. Studies
in experimental models of global and focal brain ischemia have also demonstrated tissue-saving neuroprotective
effects.