The lipase inhibitor orlistat (Xenical)
has been shown to promote additional
weight loss compared with lifestyle modifications
alone (10,11). Moreover, studies
(12,13) have shown improvement in
insulin sensitivity and glucose homeostasis
with orlistat treatment in both diabetic
and nondiabetic obese patients. Recently,
the XENDOS (XENical in the Prevention
of Diabetes in Obese Subjects) Study has
indicated that the additional weight loss
induced by orlistat reduced the development
of type 2 diabetes by 37% during the
4-year study in obese patients (14)