National Science Education Standards [8] include the teaching of molecular genetics with an emphasis on the chemical nature of DNA. Electrophoresis activities address several life science standards presented here, as well as physical science standards discussed in a later section. Within Life Science Standard C, the activity addresses standards in The Cell (#1–4, 6), Molecular Basis for Heredity (#1–3), and Biological Evolution (#1, 4, 5). Through these investigations, with teacher guidance, students gain a deeper understanding of molecular genetics. Observing the molecular nature of DNA and discussing its roles demonstrates that specific components of cells underlie specific functions and that chemical reactions are important for maintaining cell components. Observing differences between DNA extracts from various organisms, leads to a discussion of mutation, evolution of species, common ancestors, and the balance between unity and diversity in living systems through evolutionary time. Physical separation and visualization of DNA fragments with this protocol should make these abstract concepts more real for students promoting better comprehension of the academic language of the discipline.