Family pedigree of the patient with a mutations of PROS1 gene. Open square, Men with normal protein S. open circle, women with normal protein S; square with half black, men with low protein S; circle with half black, women with low protein S; square with half shaded, men with low protein S who were not available for DND analysis; circle with half shaded, women with low protein S who were not available for DNA analysis; square and circle with diagonal slash, deceased; squares and circles with dot inside, unexplored. Patient with thrombosis