Infusions of normal marrow will prevent death
from marrow failure in animals that have received
lethal doses of total body irradiation, doses
of the order of 1,000 roentgens (r.) ( 1 ). By analogy
similar infusions might be expected to be use-
.ful in treating postradiative marrow failure in man.
Two patients with leukemia requiring treatment by
radiation have been given 850 r. and 1,140 r., respectively.
Each patient had an identical twin to
serve as donor of normal isologous marrow. In
these twins it was possible to study the problems of
lethal irradiation and marrow restoration free
from the immunologic complications of homotransplantation.
It was also possible to observe
the effect of lethal irradiation upon leukemia in
man.
METHODS
The methods of obtaining, preparing, storing and
Infusions of normal marrow will prevent deathfrom marrow failure in animals that have receivedlethal doses of total body irradiation, dosesof the order of 1,000 roentgens (r.) ( 1 ). By analogysimilar infusions might be expected to be use-.ful in treating postradiative marrow failure in man.Two patients with leukemia requiring treatment byradiation have been given 850 r. and 1,140 r., respectively.Each patient had an identical twin toserve as donor of normal isologous marrow. Inthese twins it was possible to study the problems oflethal irradiation and marrow restoration freefrom the immunologic complications of homotransplantation.It was also possible to observethe effect of lethal irradiation upon leukemia inman.METHODSThe methods of obtaining, preparing, storing and
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