Acne is a chronic inflammatory disease involving the pilosebaceous unit. It is typified by the eruption of a comedo within the follicle, which is preceded by a microcomedo.1 Four main factors lead to the formation of acne lesions: (1) increased sebum production by sebaceous glands, in which androgens have an important role; (2) hyperkeratinization of the follicle, leading to a microcomedo that eventually enlarges into a comedo; (3) colonization of the follicle by the anaerobe Propionibacterium acnes; and (4) an inflammatory reaction.2 The inflammatory events may begin before hyperkeratinization of the follicle.3 Current therapies target these four factors for acute control of flare-ups and long-term maintenance.