In adults, major depressive disorder affects twice as many women as men. For both genders it is most common in those who are 25-44 years of age, and least common for those over the age of 65. In children, clinical depression affects girls and boys at about the same rate. Within an entire lifetime, major depression will affect 10%-25% of women and 5%-12% of men. At any one point in time, 5%-9% of women and 2%-3% of men are likely to be clinically depressed. Although major depression can occur at any age, the average age for developing the illness seems to be in a person's mid-20's. However, the average age of onset of the condition appears to be decreasing. Those with a parent or sibling who has had major depression may be 1.5 to 3 times more likely to develop the condition than those who do not.