For example, tricyclic antidepressants fell out of favor because they exhibited less favorable safety and tolerability than newer, more selective agents (such as the SSRIs)
the studies examined in this review do suggest that increased anxiety, agitation, and (in rare instances) mania may be associated with either product, as is thecase with conventional antidepressants.
Expectation bias of study subjects may also contribute to the low incidence of side effects reported with these products
Freeman et al demonstrated that the discontinuation rate due to adverse events in subjects receiving placebo is generally lower in studies in which a CAM treatment is compared to placebo, compared to studies in which a conventional antidepressant is compared to placebo.