Alcohol is toxic to liver cells, and many heavy drinkers develop cirrhosis, a sometimes-lethal condition in which the liver is so heavily scarred that it is unable to function. But it's hard to predict which drinkers will develop cirrhosis. "Some people who drink huge amounts never get cirrhosis, and some who don't drink very much do get it," Saitz says. For some unknown reason, women seem to be especially vulnerable.