In nature, there is universal distribution of antibiosis among the microorganisms owing to which they are involved in antagonism (Euanorasetr et al., 2010).
Those microorganisms which have capacity to produce more antibiotics can survive for longer time than the other producing antibiotics in fewer amounts. However, antibiotics produced by microorganisms have been very useful for the cure of certain human diseases caused by bacteria, fungi and protozoa. Due to continuous endeavor made in this field, the antibiotics discovered at present are about 5,500. Total world production of antibiotics is more than one million tons per annum. This success has been possible only due to continuous researches made during the last 4 decades (Walsh, 2003).