Fold And Fly
When you have to make it through the week living out of a carry-on, it's important to know a couple of tips and tricks. Heavy items, like your second pair of shoes (shoes should never be worn twice within 48 hours), go by the suitcase's wheels.
This keeps the bag maneuverable and will not put any wrinkles in your carefully folded shirts. Said shirts (of course, you bring one for each day and one extra) go into the plastic dry cleaning bags to keep wrinkles away.