We gave three bottles to each patient: one bottle with
treatment A, one bottle with treatment B and one bottle
with treatment C. If patients were randomized to orlistat,
they took one capsule by treatment A (after breakfast),
one capsule by treatment B (after lunch) and one capsule
by treatment C (after dinner). If patients were randomized
to sibutramine, two treatments of three contained
placebo. Sibutramine was present in one of these treatments
(and patients could take it after breakfast or after
lunch or after dinner). Bottles were prepared by the
hospital pharmacy; investigators collected the bottles
from the pharmacy and dispensed them to patients.