Our society’s unresolved controversy over GMOs is not about safety; it’s about whether we have an acceptable process in place to ensure that our health is not put at risk for the sake of biotech’s bottom line. Researchers, biotech companies, and regulators need to settle on an appropriately rigorous, transparent, and independent safety testing process for all new crops, one whose methods and results are publicly available. Currently, as the Nature Biotechnology review notes, safety assessments in the U.S. are a patchwork affair with weak legal underpinnings. But for GM solutions to our food challenges to be widely accepted, the public needs to know that they are not being coerced into eating something whose risks and benefits are unknown.