Andrographis paniculata, native to Taiwan, Mainland China and India, is a medicinal herb, which possesses
various biological activities including anti-atherosclerosis. Andrographolide (1) has been identi-
fied as one of the active constituents against atherosclerosis. In continuation of our drug discovery
program we synthesized few novel derivatives of 1 to improve their antidyslipidemic, LDL-oxidation and
antioxidant activity. The tosylated derivative 7 has been turned out to be more potent than the parent
compound and comparable activity with marketed antidyslipidemic drugs.