tract pathogens that have related molecular structures,
called pathogen-associated molecular patterns (PAMP).
PAMPs differ little from one pathogen to another but are
not found in the host.2 SP-A bind PAMPs located on microbial
membranes via their calcium-dependent carbohydrate-
binding domains. Independent of direct binding to
pathogens, SP-A also interacts directly with dendritic cells,
modulates subsequent T-cell responses, optimizes leukocyte
function and chemotaxis, modifies subsequent cytokine/
chemokine profiles, and activates complement. Thus,
these proteins are crucial in the initial interaction, recognition,
processing, and subsequent adaptive immune
tract pathogens that have related molecular structures,called pathogen-associated molecular patterns (PAMP).PAMPs differ little from one pathogen to another but arenot found in the host.2 SP-A bind PAMPs located on microbialmembranes via their calcium-dependent carbohydrate-binding domains. Independent of direct binding topathogens, SP-A also interacts directly with dendritic cells,modulates subsequent T-cell responses, optimizes leukocytefunction and chemotaxis, modifies subsequent cytokine/chemokine profiles, and activates complement. Thus,these proteins are crucial in the initial interaction, recognition,processing, and subsequent adaptive immune
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