Social isolation Social media can make it easy for people to connect with others, but it can also lead to social isolation. Social isolation could lead to some people feeling lonely, and other people could feel lonely without being socially isolated. This is another cause that may result in a lack of interaction with others. Social isolation is associated with an increased risk of developing mental health issues, such as depression and anxiety. Individuals loneliness are more likely to be experiencing a debilitating physical or mental health condition, are dissatisfied with their personal financial situation, or recovering from a recent negative life event. These individuals are also more likely to have fewer confidants and fewer or no nearby relatives or friends.