hortly after learning of a year-long lifespan from Werner's Syndrome, Snake is given a mission by Colonel Roy Campbell to assassinate Liquid in the Middle East. Snake infiltrates the area where Liquid's army is camped where he meets Drebin 893, a black market arms dealer, who then injects Snake with nano machines that enable him to use the latest generation of weaponry. When he finally reaches Liquid, Liquid releases a signal that incapacitates Snake and other soldiers in the area equipped with nano machines, including a patrol lead by his old comrade Meryl Silverburgh. As Snake collapses, he sees Dr. Naomi Hunter again for the first time since Metal Gear Solid.
Via an encoded message, Naomi explains she is being forced to do research for Liquid in South America and asks for Snake's rescue. Snake finds Naomi, who explains that Liquid plans to use Big Boss' biometric data as a key to access the Patriots' core AI and take control of its firearms control system, the SOP. After tests, she tells him the cause of his accelerated aging, and that the FOXDIE virus inside him will mutate within six months, spreading a deadly version of FOXDIE to the population. PMC members kidnap Naomi, and after retrieving her, Snake and Naomi make their escape out of the country with the help of Drebin and Raiden. Snake finds an Eastern Europe resistance group that have both the equipment to heal Raiden, after he was injured in a fight with Vamp, and the remains of Big Boss. Once there, EVA, leading the resistance group under the alias "Big Mama", reveals that she is the surrogate mother to Snake and Liquid Snake through the "Les Enfants Terribles" cloning project. Liquid's armed forces attack Snake, Big Mama, and the decoy vehicles pretending to transport Big Boss' remains. Snake helps Big Mama escape to the riverside, where Big Boss's remains were really kept. Liquid reveals that he no longer needs Big Boss's body, and that he has already infiltrated the system using his own system core to act as a trojan. U.S. military forces arrive, but he disables their firearms via his trojan core. Vamp throws Big Boss's body into the flames. Big Mama follows to save it. Snake's fruitless attempt to save her leaves him with a burn scar. Liquid escapes with Naomi as collateral, but Otacon's robot makes it onto Liquid's boat.
The video reveals that Liquid plans to destroy the Patriots' core AI with a nuclear strike using Metal Gear REX's railgun. Then he will substitute the core with his own to gain control. To facilitate it, Liquid needs a non ID-tagged nuclear warhead, which is to be recovered from Shadow Moses facility. Snake infiltrates Shadow Moses Island and reaches REX's hangar only to be ambushed by Vamp who has Naomi with him. Raiden joins Snake and kills Vamp. Naomi, revealing she is riddled with cancer and tormented by her mistakes, disables her nanomachines holding off the cancer and dies. Snake and Raiden use REX to head out of the hangar. As they emerge at the port area, Liquid reveals Outer Haven, a colossal submarine ready to fulfill his launch plan. Liquid orders the submarine to ram the dock Snake is on, but Raiden pushes it back. The USS Missouri (BB-63) arrives and starts firing at Outer Haven, forcing it to retreat. Aboard the Missouri, Mei Ling, as a U.S. Navy Captain, orders the battleship to intercept Outer Haven. Seizing the moment it surfaces to launch the nuke, Snake, Meryl, and Johnny board the ship via catapults. When Snake arrives at the core, he uses Otacon's robot to disable the core AI with a computer virus. The virus destroys Liquid's AI core and the Patriot system controlling the entire world, leaving the bare necessity for the modern civilization to survive. The destruction of the Patriots brings the war economy to a halt, counteracts the Patriots' upcoming civilian control scheme, and causes a mental breakdown for the enemy soldiers. Snake, after passing out in the core room, awakes atop Outer Haven's tower to find Liquid, and defeats him in combat. In the aftermath of the battle, Meryl reconciles with Campbell, and marries Johnny. At the wedding, Drebin reveals his origin as a child soldier as well as his role in Patriots' schemes. He also reveals that Meryl's unit has been an unwitting pawn used by the Patriots, but they and Drebin are now free. Otacon decides to raise Sunny to allow her to live a normal childhood. Raiden reconciles with Rose after learning that her relationship with Campbell was only a sham to protect Raiden's family from the Patriots.
In the game's epilogue, Snake attempts suicide before Big Boss arrives at the grave site with a vegetative Major Zero on a wheelchair. Big Boss explains that the body burned in Eastern Europe was actually Solidus Snake, and reveals that the Patriots were originally an interpretation of The Boss' will, founded by Major Zero, EVA, Ocelot, Sigint, Para-Medic, and Big Boss himself. While their power increased, two rival factions arose within the Patriots' ranks: Zero's, who stood for complete control; and Big Boss', who dreamed of a soldier's world. He also explains that Ocelot purposefully used nanomachines and hypnotherapy to implant the persona of Liquid as his own. Over the years, Zero let the newly established AI network assume control, eventually leading to dependence on the war economy, a vision far from The Boss' original will. Big Boss kills Zero and informs Snake that the nanomachines Drebin injected into him came with a new strain of FOXDIE, engineered by the Patriot AIs to eradicate the old strains and to kill the rival Patriot faction. Thus, Snake's presence will kill Big Boss, and Snake has no risk of becoming a biological weapon. Taking his father's words by heart, Snake then decides to live out the rest of his life peacefully with Otacon and Sunny, vowing to live long enough to see what the future holds for the new world he has helped create.
hortly after learning of a year-long lifespan from Werner's Syndrome, Snake is given a mission by Colonel Roy Campbell to assassinate Liquid in the Middle East. Snake infiltrates the area where Liquid's army is camped where he meets Drebin 893, a black market arms dealer, who then injects Snake with nano machines that enable him to use the latest generation of weaponry. When he finally reaches Liquid, Liquid releases a signal that incapacitates Snake and other soldiers in the area equipped with nano machines, including a patrol lead by his old comrade Meryl Silverburgh. As Snake collapses, he sees Dr. Naomi Hunter again for the first time since Metal Gear Solid.
Via an encoded message, Naomi explains she is being forced to do research for Liquid in South America and asks for Snake's rescue. Snake finds Naomi, who explains that Liquid plans to use Big Boss' biometric data as a key to access the Patriots' core AI and take control of its firearms control system, the SOP. After tests, she tells him the cause of his accelerated aging, and that the FOXDIE virus inside him will mutate within six months, spreading a deadly version of FOXDIE to the population. PMC members kidnap Naomi, and after retrieving her, Snake and Naomi make their escape out of the country with the help of Drebin and Raiden. Snake finds an Eastern Europe resistance group that have both the equipment to heal Raiden, after he was injured in a fight with Vamp, and the remains of Big Boss. Once there, EVA, leading the resistance group under the alias "Big Mama", reveals that she is the surrogate mother to Snake and Liquid Snake through the "Les Enfants Terribles" cloning project. Liquid's armed forces attack Snake, Big Mama, and the decoy vehicles pretending to transport Big Boss' remains. Snake helps Big Mama escape to the riverside, where Big Boss's remains were really kept. Liquid reveals that he no longer needs Big Boss's body, and that he has already infiltrated the system using his own system core to act as a trojan. U.S. military forces arrive, but he disables their firearms via his trojan core. Vamp throws Big Boss's body into the flames. Big Mama follows to save it. Snake's fruitless attempt to save her leaves him with a burn scar. Liquid escapes with Naomi as collateral, but Otacon's robot makes it onto Liquid's boat.
The video reveals that Liquid plans to destroy the Patriots' core AI with a nuclear strike using Metal Gear REX's railgun. Then he will substitute the core with his own to gain control. To facilitate it, Liquid needs a non ID-tagged nuclear warhead, which is to be recovered from Shadow Moses facility. Snake infiltrates Shadow Moses Island and reaches REX's hangar only to be ambushed by Vamp who has Naomi with him. Raiden joins Snake and kills Vamp. Naomi, revealing she is riddled with cancer and tormented by her mistakes, disables her nanomachines holding off the cancer and dies. Snake and Raiden use REX to head out of the hangar. As they emerge at the port area, Liquid reveals Outer Haven, a colossal submarine ready to fulfill his launch plan. Liquid orders the submarine to ram the dock Snake is on, but Raiden pushes it back. The USS Missouri (BB-63) arrives and starts firing at Outer Haven, forcing it to retreat. Aboard the Missouri, Mei Ling, as a U.S. Navy Captain, orders the battleship to intercept Outer Haven. Seizing the moment it surfaces to launch the nuke, Snake, Meryl, and Johnny board the ship via catapults. When Snake arrives at the core, he uses Otacon's robot to disable the core AI with a computer virus. The virus destroys Liquid's AI core and the Patriot system controlling the entire world, leaving the bare necessity for the modern civilization to survive. The destruction of the Patriots brings the war economy to a halt, counteracts the Patriots' upcoming civilian control scheme, and causes a mental breakdown for the enemy soldiers. Snake, after passing out in the core room, awakes atop Outer Haven's tower to find Liquid, and defeats him in combat. In the aftermath of the battle, Meryl reconciles with Campbell, and marries Johnny. At the wedding, Drebin reveals his origin as a child soldier as well as his role in Patriots' schemes. He also reveals that Meryl's unit has been an unwitting pawn used by the Patriots, but they and Drebin are now free. Otacon decides to raise Sunny to allow her to live a normal childhood. Raiden reconciles with Rose after learning that her relationship with Campbell was only a sham to protect Raiden's family from the Patriots.
In the game's epilogue, Snake attempts suicide before Big Boss arrives at the grave site with a vegetative Major Zero on a wheelchair. Big Boss explains that the body burned in Eastern Europe was actually Solidus Snake, and reveals that the Patriots were originally an interpretation of The Boss' will, founded by Major Zero, EVA, Ocelot, Sigint, Para-Medic, and Big Boss himself. While their power increased, two rival factions arose within the Patriots' ranks: Zero's, who stood for complete control; and Big Boss', who dreamed of a soldier's world. He also explains that Ocelot purposefully used nanomachines and hypnotherapy to implant the persona of Liquid as his own. Over the years, Zero let the newly established AI network assume control, eventually leading to dependence on the war economy, a vision far from The Boss' original will. Big Boss kills Zero and informs Snake that the nanomachines Drebin injected into him came with a new strain of FOXDIE, engineered by the Patriot AIs to eradicate the old strains and to kill the rival Patriot faction. Thus, Snake's presence will kill Big Boss, and Snake has no risk of becoming a biological weapon. Taking his father's words by heart, Snake then decides to live out the rest of his life peacefully with Otacon and Sunny, vowing to live long enough to see what the future holds for the new world he has helped create.
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