Hyperglycemia has also been previously shown to be associated with the development of ROP. In a study by Garg et al. evaluating hyperglycemia and the development of Stage III or IV ROP, it was shown that for each 10 mg/dL increase of mean serum glucose, there was 2.7-fold increase in the risk of developing ROP [14]. Blanco et al. also found that hyperglycemia was associated with a 4.5-fold increase in the incidence of ROP in a Hispanic population of ELBW infants [18]. In a recent study by Kaempf et al., hyperglycemia and insulin exposure was shown to be associated with higher stages of ROP [15]. In our study, we have shown that the duration of hyperglycemia is a significant risk factor in the develop- ment of ROP, with each day of hyperglycemia increasing the risk by 7% in a population of ELBW infants who did not receive insulin therapy. Studying infants who did not receive insulin therapy allowed us to investigate the role of hyperglycemia in the incidence of ROP independently of insulin exposure. Our study also shows that duration of hyperglycemia is associated with ROP, building on previous studies that chose highest glucose at one time point to define hyperglycemia.
Hyperglycemia has also been previously shown to be associated with the development of ROP. In a study by Garg et al. evaluating hyperglycemia and the development of Stage III or IV ROP, it was shown that for each 10 mg/dL increase of mean serum glucose, there was 2.7-fold increase in the risk of developing ROP [14]. Blanco et al. also found that hyperglycemia was associated with a 4.5-fold increase in the incidence of ROP in a Hispanic population of ELBW infants [18]. In a recent study by Kaempf et al., hyperglycemia and insulin exposure was shown to be associated with higher stages of ROP [15]. In our study, we have shown that the duration of hyperglycemia is a significant risk factor in the develop- ment of ROP, with each day of hyperglycemia increasing the risk by 7% in a population of ELBW infants who did not receive insulin therapy. Studying infants who did not receive insulin therapy allowed us to investigate the role of hyperglycemia in the incidence of ROP independently of insulin exposure. Our study also shows that duration of hyperglycemia is associated with ROP, building on previous studies that chose highest glucose at one time point to define hyperglycemia.
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